Catching and releasing tiny molecules | Harvard School of Engineering and Applied Sciences

New technique for sorting biomolecules could lead to efficient clinical diagnostics and chemical purification

Source: www.seas.harvard.edu

The new microfluidic device, described in a paper appearing today in the journal Nature Chemistry, is composed of microscopic “fins” embedded in a hydrogel that is able to respond to different stimuli, such as temperature, pH, and light. Special DNA strands called aptamers, that under the right conditions bind to a specific target molecule, are attached to the fins, which move the cargo between two chemically distinct environments. Modulating the pH levels of the solutions in those environments triggers the aptamers to “catch” or “release” the target biomolecule…

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